What is the role of the hypothalamus in temperature regulation? Temperature is usually the order of magnitude more important than energy in mammalian behavior, so thermographic examinations of brain tissue of mouse showed the most prominent role of the hypothalamus. Recent researches are able to depict hypothalamic changes in humans that they can identify, but the actual role of the hypothalamus in temperature regulation has not yet been elucidated. It was shown that hypothalamus are involved in the nervous system (including various types of neurons for example, cortex, platelets, gray and white matter), and that they have a specific function, such as a circadian or diurnal regulation, not to regulate physiological temperature condition. The hypothalamus is an important sensor of the changes of temperature within a living body and it is therefore of considerable significance if further studies are to be applied to understanding the functions and roles of the hypothalamus in the proper physiological operation. 1st century? What is the role of the hypothalamus in metabolic regulation? Most studies have been performed to localize the hypothalamic organization of metabolism in mammals and for the study of the cause and effect in humans. 2nd century? What is the mechanism for generating neurons? It was shown that the hypothalamus works as an important player for the regulation of the metabolic apparatus, whereas to the study of the effect of substances on neurons it is important to elucidate the role of the hypothalamus in the regulation of the cellular and molecular cellular behavior. Not exactly, but the function of the hypothalamus is to be investigated in the next few decades. That is the work of Zhang, Shao, and Yang [Figure 1](#F1){ref-type=”fig”}. The work of Zhang is an exploratory research and evaluation by their special office. Even though Zhang and Shao did not analyze the molecular mechanism in detail with their laboratory, they succeeded in explaining their research results in scientific form. This is only the first part of the review. 